Pseudomembranous enteritis is an acute fibrinous exudative inflammatory disease occurring mainly in the colon and small intestine. It is mostly caused by dysbiosis of the normal intestinal flora after the application of broad-spectrum antibacterial drugs, which results in the proliferation of drug-resistant Clostridium difficile and the production of toxins. For the treatment of pseudomembranous long-term, the first thing should be to immediately stop the original antibacterial drugs and avoid the use of cleansing agents and antidiarrheal agents to prevent the retention of toxins in the intestine. At the same time, for patients with severe disease, supportive therapy should be intensified to correct water-electrolyte disorders, replenish blood volume, replenish plasma and human albumin, and strengthen the patient’s resistance. In addition, effective drugs for the cause of the disease, such as metronidazole and vancomycin, can be applied, and drugs containing Lactobacillus acidophilus and Bifidobacterium bifidum can be chosen for oral administration. To restore the normal intestinal flora, enemas can also be applied to achieve results. In addition, in severe cases with poor response and repeated recurrence, surgical management needs to be considered if necessary to avoid symptoms of haemorrhage and perforation.