According to 2012 statistics, colorectal cancer became the third most prevalent tumor in the world, accounting for 9.7% of the tumor incidence rate. According to the 2010 Chinese tumor epidemiology data, the incidence of malignant tumors in Shanghai is increasing year by year and has exceeded the national incidence of malignant tumors, which is related to the serious aging of Shanghai’s population and the increase of life expectancy of the population. The current situation we are facing is: the incidence of malignant tumors continues to rise; the incidence of colorectal cancer continues to rise (the incidence of colorectal cancer in Shanghai is increasing at the rate of 4.2% per year); the mortality rate of colorectal cancer continues to be high; the survival rate of colorectal cancer is extremely different from the international level, and the form of prevention and control is very severe. Drawing on foreign experience, we actively promote tertiary prevention of colorectal cancer. Whether in the diagnosis or treatment of malignant tumors, there is a big gap between China and the international advanced level. Take the United States as an example, the incidence rate and mortality rate of colorectal cancer in the United States have been declining for 20 consecutive years. Primary prevention aims to change lifestyle; secondary prevention focuses on screening and timely treatment of precancerous lesions; tertiary prevention (i.e. clinical treatment) focuses on the selection of appropriate drugs for standardized multidisciplinary treatment. Tertiary prevention measures reduce the incidence and mortality rate of colorectal cancer and increase the 5-year survival rate. Professor Cai pointed out that primary prevention plays a role in 35% of the “two decreases and one increase” of colorectal cancer, secondary prevention accounts for 53%, which is the most important, while tertiary prevention only accounts for 12%. So what are the more important primary and secondary preventions? Primary prevention (lifestyle changes) includes reducing the intake of high-protein, high-fat, fine, pickled and fried, smoked food; increasing the consumption of vegetables, fruits and coarse grains; reducing smoking and excessive alcohol consumption; strengthening exercise and reducing obesity. Secondary prevention (early detection and treatment) includes actively promoting the clinical manifestations of colorectal cancer to achieve timely diagnosis; actively carrying out screening and census to achieve timely detection; and actively treating precancerous lesions to reduce the occurrence of colorectal cancer. Combined with the colorectal cancer screening programs in Europe and the United States (Table), Prof. Cai highlighted the implementation process of the colorectal cancer screening promotion route, through preliminary studies, large-scale randomized controlled trials (RCT) or case-control studies, thus releasing screening standards, through medical insurance coverage and government promotion, and finally forming a screening system. Shanghai colorectal cancer screening program has conducted the first round of first year screening in 2013, hoping to play an active and effective role in reducing the incidence, mortality rate of colorectal cancer in Shanghai. What can each clinician do to reduce the incidence of colorectal cancer and improve the quality of patient survival? Tertiary prevention includes standardized multidisciplinary individualized treatment (standardized execution of pre-treatment diagnosis, standardized treatment plan design, standardized multidisciplinary individualized treatment, and standardized post-treatment follow-up); secondary prevention includes active participation in research, promotion and implementation of screening and screening, and active management of precancerous lesions; and primary prevention includes active promotion of good lifestyle and diet. Finally, Prof. Tsai emphasized that every doctor is not only a healer but also a preventor! Only by popularizing to the public the correct concepts of lifestyle change, timely consultation, active participation in screening and screening, active treatment of precancerous lesions, and standardized treatment of clinical tumors can we reduce the incidence and mortality of colorectal cancer and improve the survival quality of colorectal cancer patients.