Itchy rash is a kind of inflammatory skin disease characterized by windswept pimples, nodules and strange itching. It can be treated by topical medication and oral medication, which can relieve and alleviate the disease. Itchy rash mostly occurs on the limbs, the course of the disease is relatively slow, with papules and nodules as the main damage, accompanied by intense itching as the main manifestation. Itchy rash has no particularly effective cure at present, only to relieve and alleviate the symptoms. 1. Topical medications: glucocorticosteroids can be given (such as dexamethasone ointment, tretinoin cream, mometasone furoate cream, etc.), sealing can enhance the efficacy of nodular lesions can be used to glucocorticosteroids intradermal injection. 2. Oral medication: antihistamine medication, such as loratadine, cetirizine, ebastine and so on. Patients with generalized rash and severe symptoms can be treated with small-dose glucocorticosteroids for a short period of time. Patients with neuropsychiatric factors can be appropriately given sedatives and hypnotics, such as diazepam and eszopiclone. Patients with itchy rash, must go to the regular hospital, follow the doctor’s instructions for medication.