The time for transaminase 240 U/L to fall to 40 U/L is closely related to the etiology and treatment. If there is a transient aminotransferase elevation to 240U/L, it can be reduced to 40U/L within 1-2 weeks after active treatment. Other aminotransferase elevations caused by viral hepatitis require different times depending on the type of disease. 1. Within 1-2 weeks: It is common for abnormally elevated aminotransferases caused by taking liver-damaging drugs or long-term heavy drinking, after active liver-protective and enzyme-lowering treatment, it can be choose other types of drugs under the guidance of doctors, or after abstaining from alcohol and then take medication, generally the transaminase can be restored to 40U/L within 2 weeks; 2, about 2 weeks: if the patient with hepatitis A or hepatitis E has elevated transaminase to 240U/L, after liver-protective and enzyme-lowering treatment, the condition may be cured in about 2 weeks and the transaminase may return to normal; 3, about 4 weeks: if the patient with chronic hepatitis B, chronic hepatitis C, while liver-protective and enzyme-lowering treatment, antiviral treatment is also needed, such as patients with chronic hepatitis B need to take entecavir or tenofovir for antiviral treatment, while taking liver-protective and enzyme-lowering drugs, such as silymarin, compound glycopyrrolate and other combined treatment, transaminases can generally return to normal in about 4 weeks, but antiviral drugs cannot be stopped and need to be taken for a long time, otherwise transaminases may rise again. Otherwise, transaminases may rise again; 4. More than 4 weeks: If the elevated transaminases are caused by cirrhosis, it will take longer to recover to normal or be difficult to recover because the liver has undergone organic changes. If the high transaminases are caused by liver cancer, surgical treatment and other adjuvant treatments are needed before the transaminases can be restored to normal. In addition, after active treatment, the patient’s transaminases return to normal range, the patient can continue to take medication according to the doctor’s suggestion in order for the patient’s transaminase value to continue to be within the normal range.