The goal of surgical treatment is to obtain R0 resection with maximum preservation of function. The patient should be evaluated as a whole by an experienced surgeon prior to surgery. Amputation should only be considered if the patient requires amputation or if removal of the entire tumor would result in a function of the affected limb that is not superior to that of a prosthesis. With the advancement of modern surgical techniques and concepts, the previous contraindications for limb preservation are no longer applied, such as vascular involvement can be replaced by autologous or artificial vessels, nerve involvement can be removed and inactivated by neuroepithelium, and sometimes even neurectomy residual limb can be used to obtain better function than prosthesis through the use of orthopedic brace. The latest NCCN guidelines provide different clinical pathways according to whether soft tissue sarcoma is resectable or not, but there is no definition of resectability of soft tissue sarcoma to date, and due to the different centers and regions of the world, there is no definition of resectability of soft tissue sarcoma. However, there is no definition of resectability of soft tissue sarcoma, and there are different assessments of resectability due to differences in surgical techniques, equipment, philosophy, and patient preferences among different centers and regions. Intraoperative radiotherapy, post-mounted radiotherapy, and particle implantation can be used as adjuvant therapy to improve local control when vital structures are preserved and margins are <1 cm. Therefore, resectability of soft tissue sarcoma of the limb is a preoperative concept and should be defined as the integration of a combination of therapeutic approaches that are expected to achieve safe margins and preserve acceptable limb function.