This morning I saw a lip infection patient holding a Tretinoin ointment and shouting “Lip infection medication, my life saver, I hope I get better soon!” I instantly thought it was time to educate everyone on what retinoic acid ointment is and under what circumstances it should be used. Last night just to the oral surgeons on the oral mucosa plaque type of disease, which speaks of white spots, oral lichen planus and oral mucosa white fibrosis these diseases when there is talk about the use of retinoic acid ointment method, now to share with you: xinyi people’s hospital stomatology department Feng Qiujing retinoic acid ointment instructions have explained that its main component is all-trans retinoic acid, chemical name: 9, 13-dimethyl-7 One of the significant pharmacological activities of [-(1,1,5-trimethylhex-5-cyclohexen-6)-7,9,11,13-nonatetraene-15 acid] is the induction of epidermal proliferation, thickening of the granular and spiny cell layers, and the increase in DNA synthesis and mitotic index seen in the affected epidermal cells. Another important effect is to promote the differentiation of epidermal granular layer cells to the stratum corneum by affecting the enzymatic cleavage of K1 and K10 keratin, the process of filoproteinogen to filoprotein and the formation of cross-linked envelopes during the late stage of epidermal differentiation. Retinoic acid significantly inhibits the generation of experimental acne and prevents and eliminates acne lesions by regulating the abnormal process of epithelial keratinization in the sebaceous glands of hair follicles and removing keratin plugs. Retinoic acid affects melanogenesis in melanocytes and inhibits the activity of tyrosine hydroxylase, dopa oxidase and dihydroxyindole oxidase, which reduces melanin formation and skin pigmentation. Vitamin A acid has no effect on melanocyte tyrosinase activity and melanin composition in normal humans. When the skin undergoes physiological aging or is injured by drugs, ultraviolet radiation and trauma, retinoic acid can correct or prevent abnormalities in the biochemical composition and morphological structure of dermal connective tissue caused by harmful factors, stimulate the synthesis of extracellular matrix proteins in the skin, accelerate the formation of new connective tissue bands in the upper dermis, and improve the tension strength of the wound site. Retinoic acid has no effect on normal skin collagen synthesis. In addition, retinoic acid has an inhibitory activity on leukocyte chemotaxis, thus acting as an anti-inflammatory agent. From the above pharmacological effects we can see that the conditions to be treated with retinoic acid need to be met is the presence of dyskeratosis or incomplete keratinization in the epidermis of the patient, if they do not have these conditions themselves use is a certain risk. At the same time, the instructions for precautions are written: 1, eczema, sunburn, acute and subacute dermatitis, rosacea patients should not be used. 2, should not be used on the skin folds. 3. Do not use other drugs, cosmetics or cleansers that can cause skin irritation and breakage during the medication period to avoid aggravating skin reactions, increasing drug absorption and causing systemic adverse reactions. 4.Sunlight can aggravate the skin irritation of retinoic acid leading to the decomposition of retinoic acid, animal experiments suggest that retinoic acid can enhance the carcinogenic ability of ultraviolet light, so this product is most suitable for application at night and before bedtime, the treatment process should avoid sunlight, or the use of shading measures. 5.This product should not be applied to a large area, and the daily dosage should not exceed 20g. 6.Because this product may cause severe irritation and flaking, the treatment plan of using the drug every other day or once every 3 days can be adopted at the beginning; it is better to use a low-concentration preparation first, and then switch to a higher-concentration preparation after it is tolerated. It is clear from the precautions that since retinoic acid is not light-proof and needs to be used away from light, it should not be used alone for topical treatment in diseases where sunlight irritation can cause morbidity (such as discoid lupus erythematosus). Moreover, it is not advisable to use retinoic acid for diseases with recurrent flaking manifestations (such as dry flaking labialis). It is safer to use it in accordance with its indications: Vital Acid Ointment is used as an adjunctive treatment for acne vulgaris, lichen planus, mucous membrane leukoplakia, hair erythroderma, follicular keratosis and psoriasis. Acne vulgaris: Apply the medicine gently to the affected area once a night before bedtime. Psoriasis, ichthyosis and other rashes located in covered areas can be applied 1-3 times a day or as prescribed by the doctor.