Remember Chen Yurong, the “Stampede Mom” who moved China in 2009? In order to “cut her liver to save her son”, the 55-year-old walked 10 kilometers a day for 7 months, and finally her fatty liver disappeared completely, and this mother’s story touched countless people. So what is fatty liver? Fatty liver is a condition in which the fat in the liver exceeds 5% of the wet weight of the liver (normal is 3%-4%), and non-alcoholic fatty liver is simply a fatty liver that is not caused by alcohol consumption. Globally, NAFLD has become one of the most common chronic diseases, along with obesity and type 2 diabetes. The prevalence of NAFLD is 17 – 33% and in the United States is 5.7 – 5.7%. Ji Guang et al. of the Department of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, recently published an article showing that vitamin E is effective in relieving the symptoms of NAFLD and reviewed the latest clinical research progress on the use of vitamin E alone and in combination with other drugs. The article was published in the January 2014 issue of the International Journal of Clinical Medicine, an English-language journal from Research Press. Non-alcoholic fatty liver disease (NAFLD) is a disease closely associated with oxidative stress, and vitamin E (VE) is a potent antioxidant that may alleviate the symptoms of NAFLD by improving the balance of oxidation and antioxidation. However, recent studies have shown that the functions of vitamin E are no longer limited to antioxidant mechanisms, but also include the regulation of disorders of glucose and lipid metabolism. To date, however, the efficacy of VE in the treatment of NAFLD remains controversial, as well as the appropriate patient conditions, drug dosage, safety and clinical course still need to be discussed. Currently, the basis of NAFLD treatment remains lifestyle interventions, but of course simple lifestyle interventions are not sufficient because it is limited in patient treatment and few patients are able to adhere to exercise and weight loss. Since the development of NAFLD is caused by multiple factors, a combination of lifestyle changes and medications is the most appropriate treatment strategy. Considering that our daily intake of vitamin E is lower than the recommended dose and that vitamin E is less expensive than any other medication, there is a need for appropriate vitamin E supplementation in addition to lifestyle changes. In the article, the authors evaluate in detail the clinical effectiveness, as well as the safety of vitamin E alone and vitamin E combined with vitamin C and ursodeoxycholic acid (UDCA), noting that patients with diabetes mellitus with NAFLD are not suitable for treatment with vitamin E.