The main diagnostic basis (a) Microangiopathic hemolytic anemia 1. anemia: mostly orthocytic or hematocrit moderate to severe anemia. 2. Microangiopathic hemolysis: (1) Jaundice with dark urine occasionally seen as hemoglobinuria. (2) More aberrant red blood cells (>2%) and red blood cell fragments are seen in the blood film. (3) Reticulocyte count is elevated. (4) Bone marrow compensatory hyperplasia with a predominantly red lineage and a decreased granulocyte/red ratio. (5) Elevated blood bilirubin with a predominance of indirect bilirubin. (6) There may be elevated plasma free hemoglobin and decreased hemoglobin-binding protein with elevated lactate dehydrogenase. (2) Thrombocytopenic purpura and bleeding tendency (1) Different degrees of purpura and other bleeding manifestations. (2) Decreased platelet count with huge platelets in blood film. (3) Increased number of megakaryocytes in the bone marrow with impaired maturation. (C) Neuropsychiatric abnormalities: according to the characteristics of transient recurrent diversity and variability such as headache personality changes mental abnormalities sensory and motor disorders convulsions positive pathological reflexes. (iv) renal damage: mainly manifested by abnormal laboratory test results such as positive urine protein erythrocytes leukocytes and tubular blood urea nitrogen creatinine elevated occurrence of renal failure is rare. (E) Fever: mostly low to moderate.