Preventive vaccination may refer to vaccination, vaccination leads to thrombocytopenic purpura, may be caused by the patient’s allergy to vaccine components, may also be caused by other reasons, such as thrombocytopenia is not caused by vaccination. 1. Some patients have a special physical condition, and the relevant components of the vaccine can lead to immune dysfunction of the patient’s body, causing the patient’s body to produce a large number of antibodies leading to thrombocytopenia, which in turn causes thrombotic thrombocytopenic purpura. 2. However, thrombocytopenic purpura is not necessarily caused by vaccination, because thrombocytopenic purpura can be secondary to drugs, infections, tumors, autoimmune diseases, leukemia and other diseases. The above diseases may not have clinical manifestations in the early stage and the patient is not aware of them. However, after vaccination, patients may have fever and other discomforts, and when they go to the hospital due to fever and other discomforts, they will find out that they have suffered from thrombocytopenic purpura through routine blood tests and other tests. Thrombocytopenic purpura after vaccination patients need to consult a doctor in a timely manner, under the guidance of a physician to clarify the diagnosis and receive standardized treatment.