Xiao Dong’s uncle Jianguo’s right nasal cavity flowed clear water intermittently for 10 days, and the clear water increased when he bent his head down and exerted himself. 4 years ago Jianguo was treated with craniotomy in a local hospital for a traumatic brain injury in a car accident (details unknown), and he recovered well after the operation without nasal flow. The diagnosis of cerebrospinal fluid rhinorrhea was made clearly by a positive urine glucose test paper on Jianguo’s nasal water. CTA and MRI of the head showed that Jianguo’s right posterior frontal sinus wall had a 2.0*1.5cm range of bone defect and fluid flowed downward in the lateral frontal sinus cavity. Through literature search, this kind of cerebrospinal fluid nasal leak belonged to one kind of refractory cerebrospinal fluid nasal leak at home and abroad, for the reason that the posterior frontal sinus wall was not easy to grow after repair by pressure impact, and the leak was not easy to find by leaning outward. The dura mater of the posterior wall of the frontal sinus was exposed by opening the bottom wall of the frontal sinus through the nasal endoscope, but due to the large bone defect, the leak could not be exposed, so a small incision of 1 cm was made from the medial side of the arch of the eyebrow, and the endoscope entered to find the leak and filled the nasal cavity with muscle fascia repair. After the operation, the patient returned to the general ward without ICU observation, reducing the patient’s financial burden, and the patient did not need lumbar puncture to place a drainage tube, reducing the patient’s pain. Through 10 days of bedside treatment, the patient recovered completely, and Jianguo has now resumed normal work and study for more than six months after surgery. He is very grateful to us for the treatment. Xiao Han was only 23 years old due to a car accident causing multiple craniofacial fractures and cerebrospinal fluid nasal leakage, had a near loss of life due to intracranial infection, and still had cerebrospinal fluid nasal leakage after controlling the infection, through transnasal endoscopic cerebrospinal fluid nasal leakage repair, intraoperative structural disorder of the pterygoid sinus was seen, multiple leaks were visible, bone was ground out, and fascial repair was performed, and Xiao Han was discharged successfully 2 weeks after the operation. Xiao Meng is a patient with a huge pituitary tumor, who experienced craniotomy, radiotherapy, and medication about 10 years ago, and then failed after 3 cerebrospinal fluid nasal leak repairs in major hospitals, had 4 intracranial infections, and had various problems such as liver function abnormalities, and all famous hospitals nationwide had given up treatment. 4 years ago, he came to me for consultation, and through imaging, it was found that Xiao Meng’s skull base structure was sunken and the surrounding normal structures disappeared, so if After endoscopic examination, it was found that the patient’s leak was located on the left posterior nasal septum, and after filling the leak under local anesthesia nasal endoscopy to seal and reinforce it, the patient’s liver function returned to normal 3 days after surgery, and there was no recurrence in 3 years of follow-up. 1 year ago, due to trauma, another nasal leak was repaired under general anesthesia via nasal endoscopy for cerebrospinal fluid nasal leak, and the patient recovered well after surgery. Zhang Ying, a 50-year-old, middle-aged female, was admitted with the diagnosis of spontaneous cerebrospinal fluid rhinorrhea, and experienced 2 surgeries within 3 years for recurrence. After admission, high intracranial pressure was detected and diagnosed as benign intracranial hypertension syndrome, and imaging revealed that the leak was located in the posterior part of bilateral corns, and transnasal endoscopic repair of cerebrospinal fluid rhinorrhea at the skull base was given, during which the bone was ground out and the skull base was repaired with fascia, and the patient was flat in bed for 20 days after surgery and no longer After the operation, the patient was bedridden for 20 days and no more nasal leakage, and there was no recurrence in six months of follow-up. After clinical practice, we have rich experience in the diagnosis and treatment of cerebrospinal fluid rhinorrhea. The causes of cerebrospinal fluid rhinorrhea can be divided into traumatic and non-traumatic, of which traumatic can be divided into traumatic and medical; non-traumatic can be divided into spontaneous, neoplastic and congenital. The main potential risk of cerebrospinal fluid nasal leakage is the possibility of intracranial infection at any time, so it should be actively treated after detection. Although 70% of trauma patients can stop nasal leakage after conservative treatment, 40% still have life-threatening intracranial infections of unknown origin, so we advocate aggressive surgery. Transnasal endoscopic repair of cerebrospinal fluid rhinorrhea is widely used in cerebrospinal fluid rhinorrhea repair because it simplifies the surgical procedure, causes less pain (no postoperative lumbar drainage), shortens the operative time, improves the accuracy and success rate, and reduces postoperative complications. Its advantages [are]: (1) the fistula hole can be viewed directly, and the fistula hole can be repaired with minimal damage; (2) the path is simple, with little damage and no facial scars; (3) the recovery is fast, with little cost and short hospital stay; (4) intracranial damage and brain tissue defects can be avoided; postoperative observation in the intensive care unit is not required; (5) its success rate of repairing cerebrospinal fluid nasal leak in one pass is significantly higher than that of intracranial or external nasal pass methods; (6) the structure and function of the organ are preserved to the maximum extent. function. It is an ideal surgical method for the treatment of traumatic refractory cerebrospinal fluid rhinorrhea.