[Abstract] Objective To investigate the method and efficacy of neuroendoscopic technique in the treatment of cerebrospinal fluid (CSF) nasal leakage. Methods To analyze the clinical data of 5 patients with CSF rhinorrhea treated with neuroendoscopic technique from November 2012 to April 2013 in our department, and to summarize the diagnosis method, surgical method and clinical effect. The CSF nasal leak after trauma was identified by cranial MR scan + enhancement, CT thin scan skull base reconstruction and CT brain pool imaging before surgery. All patients with CSF rhinorrhea were cured after surgery without complications, and no recurrence was observed for more than 3 months after follow-up. The combination of MR plain + enhancement, CT thin-scan skull base reconstruction and CT brain pool imaging can improve the accuracy of localization of traumatic CSF nasal leaks, and the localization of CSF nasal leaks of medical origin can be based on clinical experience.