Parkinson’s disease overview: Do you really understand Parkinson’s disease?

  Parkinson’s disease (PD) is a common neurodegenerative disease of the middle-aged and elderly, characterized by four major motor symptoms: resting tremor, muscle stiffness or rigidity of the extremities, slow movement, and postural balance disorder.  Resting tremor means that the hand trembles constantly when it is stationary, with the tremor of the thumb, index finger and middle finger being the most obvious, manifesting as the movement of the fingers like rolling pills or counting bills, and intensifying when tense, disappearing after sleep.  Muscle tonus is the perception of resistance to movement. Muscle tonus causes everyday movements such as turning, standing up, tying shoelaces, and unbuttoning to become slow (bradykinesia) and increasingly difficult. Postural balance disorders can manifest as small, wobbly walks and a lack of the back and forth arm swing that accompanies normal walking, frequent instability when turning, and difficulty when stopping walking.  In addition to these four major motor symptoms, Parkinson’s disease can also manifest as non-motor symptoms such as decreased sense of smell, constipation note, night sweats, slow speech, slurred speech, slowed thinking, and depression.  Patients usually begin to experience symptoms at the age of 50 to 60, but some patients experience symptoms earlier.  The cause and pathogenesis of Parkinson’s disease are not yet clear, and may be related to aging, toxic substances, and genetic abnormalities. It is now mostly believed that Parkinson’s disease may be caused by disorders of dopamine metabolism in the substantia nigra striata.  Parkinson’s disease is progressive, which means that the disease gets progressively worse over time. Usually, the process is slow and often lasts for several years.  There is no effective cure for Parkinson’s disease, but medication or surgery can reduce symptoms and improve a patient’s quality of life.  In addition to medications and surgery, Parkinson’s disease should also focus on rehabilitation, psychotherapy and care. As Parkinson’s disease patients have many inconveniences in life, relatives or caregivers should give more care and attention: choose clothes that are easy to put on and take off, and try to wear shoes without laces; encourage patients to do more active exercises, such as dressing, washing, brushing teeth and eating; create a relaxed and harmonious family atmosphere, encourage patients to overcome emotional excitement and tension, and maintain a more pleasant mood.  Although Parkinson’s disease is currently incurable and can seriously affect the patient’s daily life and work, and even cause disability, Parkinson’s disease itself is not a fatal disease and generally does not affect life expectancy. Although the disease itself is not fatal, due to the presence of motor and coordination disorders, patients can be more prone than the general population to accidents such as falls, and serious complications such as pneumonia, fractures, urinary tract infections, and asphyxia, which can be a direct cause of death.  The key to the treatment of Parkinson’s disease is early diagnosis and early treatment, so once symptoms of suspected Parkinson’s disease are detected, patients should go to professional medical institutions in a timely manner.