Patients and friends must have the feeling that our rheumatology department likes to tell patients to check their blood routine, liver and kidney functions frequently, as often as once a week or at least once every 2 months. Sometimes you may wonder why this is so. Are they “fooling” the patients? Of course, this is certainly not the case, rheumatology patients need to regularly review the blood routine, liver and kidney function is the reason: 1, rheumatology commonly used drugs may affect the blood routine, liver and kidney function, resulting in risk: rheumatology most commonly used drugs methotrexate, leflunomide, azathioprine, cyclophosphamide, etc. have led to myelosuppression (that is, leading to a decrease in the ability of bone marrow hematopoietic), liver function damage adverse reactions, while some drugs such as cyclosporine and tacrolimus may lead to impaired renal function. Although these drugs are safe for most people (otherwise doctors would not use them), there are still a small number of patients who can develop these functional impairments and even serious adverse consequences. But unfortunately, with the current level of medical care, doctors are not able to predict in advance which patients will be at risk. The only way to do this is to use a dead-end solution: diligent screening. Once the risk or the first signs of risk are detected, the drug is promptly stopped or switched to another drug. Generally speaking, the drug caused by abnormal blood count, liver and kidney function abnormalities, can be restored after discontinuation, so relatively increase the frequency of examination, will greatly reduce the risk of taking drugs. Rheumatic diseases can cause abnormal blood routine, liver and kidney function: rheumatoid arthritis, dry syndrome, systemic lupus erythematosus, autoimmune liver disease, gout and other rheumatic diseases may cause abnormalities of the above indicators, and even life-threatening in serious cases (such as severe platelet depression, granulocyte deficiency, acute deterioration of kidney function). Regular review of these indicators can monitor changes in the condition and adjust the medication in time! However, the frequency of monitoring varies greatly depending on the time of patients taking medication, the type of medication taken, and the type of disease. These patients do not need to know too much, but must be completed carefully according to medical advice. Do not take long-term without monitoring these indicators, once the risk occurs, it is too late to regret!