Perforation of otitis media is mainly seen in purulent otitis media, small perforation may partially heal by itself; if the perforation is too large, or the perforated otitis media is not treated timely and effectively, the possibility of self-healing is smaller. Purulent otitis media is mainly due to the accumulation of inflammatory exudate inside the tympanic cavity gradually turning into purulent material, which leads to local necrosis and rupture for a long time, and perforation of the tympanic membrane, and the pain is usually alleviated after the perforation. Smaller perforations may have a tendency to heal on their own after the inflammation is eliminated. If the tympanic membrane perforation is not promptly drained and treated, resulting in repeated pus flow, it may aggravate the symptoms, hearing loss, or even deafness, etc., and this type of perforation cannot be self-healed. When perforation of otitis media is found, it should be treated in time to control the infection, drain the pus, and repair the tympanic membrane by tympanoplasty if the tympanic membrane cannot heal by itself.