Cleft lip and palate is a common congenital malformation. For every 600-700 newborns born, there is one child with cleft lip and palate, which imposes a heavy psychological and economic burden on families and society. The etiology can be summarized into two main categories: genetic causes and environmental causes. The current treatment has formed a three-dimensional treatment model including orthopedic-surgical-orthodontic-phonological for restoring normal anatomical and physiological functions, i.e. a multidisciplinary sequence of cleft lip and palate treatment. This requires the integrated application of orthopedic surgery, speech pathology, oral and maxillofacial surgery, otorhinolaryngology, psychosomatic, gynecology, pediatrics and other close table work of specialists in various disciplines. The word “sequence” means order and sequence, which means the sequence of time; “column” means column of ranks, which means multiple disciplines are involved in this case from a horizontal perspective. Each participating discipline works in an organized manner according to the characteristics of different periods of cleft lip and palate, which is the “sequence”. (1) The fetal period is characterized by ultrasound identification of cleft lip and palate deformities, counseling, advising and reassuring the parents of the child, and family education and support regarding fetal treatment options. (2) 1 to 3 months of age for general examination, feeding education, and preoperative orthodontics if necessary. (3) Unilateral cleft lip repair at 3-6 months and bilateral cleft lip repair at 6-12 months. (4) Cleft palate surgery should be performed at 1.5-2 years of age. (5) A thorough examination should be performed at 6-8 years of age to consider the need for pharyngeal flap surgery, second-stage revision of secondary lip deformities, and pharyngeal cavity plication based on their phonological pathology. (6) Preoperative orthodontic treatment for alveolar split implants and alveolar cleft implants should be started at the age of 9 to 11 years. (7) Full orthodontic treatment will be started at 14 years old to align the teeth. (8) At the age of 14 to 16, the growth and development of the child has been basically completed, facing the critical period of social development, it is necessary to perform the correction of nasolabial deformity, and it is necessary to strengthen the psychological counseling and treatment. (9) Orthognathic surgical treatment after the age of 18. The doctor should discuss and develop an individual treatment plan according to the individual patient’s deformity and the status of the previous treatment, as long as their financial ability allows.