Migraine sufferers are well aware that their pain is severely life debilitating and that the pain has a gender-specific phenotype, with studies showing that women suffer from migraines three times more often than men. Although the cause of this gender difference has not been determined, it has been suggested that it is inseparably related to female hormones. Migraine is characterized by throbbing-like pain, which usually occurs on one side of the head. It can be moderate to severe pain and can last from 4 to 72 hours. These headache episodes are usually accompanied by nausea, vomiting and extreme sensitivity to light and sound. In some cases, people have signs before or during a migraine, which are some neurological symptoms that may include seeing flashes of light, having blind spots or tingling on the side of the face or in the arms or legs. We don’t know why women are more likely to suffer from migraines than men, but studies have shown that headaches are more likely to be triggered during periods of changing hormone levels in women. There are three periods of high headache prevalence: first, when girls first menstruate, the likelihood of migraines increases; second, after childbirth, the risk of migraines increases; and third, when menopause is reached, roughly 40 percent of women suffer from migraines. Up to 70% of women with migraine report a correlation between the onset of their migraine and their menstrual period. The typical onset of menstrual migraine is from one to two days before the onset of menstruation and lasts one to two days after the onset of menstruation. During pregnancy, when estrogen levels were elevated, most women reported improvement in their migraines. However, after childbirth, estrogen levels drop dramatically and women may experience severe migraines. During menopause, women may experience migraines more frequently due to a sudden drop in estrogen levels. And after the mandatory menopause, most female patients experience migraine attacks significantly less frequently. These symptoms and studies all point to a larger group of migraine attacks in women than in men, and a significant factor in triggering headaches due to the endocrine variability in women.