Premature ovarian failure refers to ovarian failure before the age of 40 in women who have established normal menstrual patterns due to follicular depletion, atresia, or medical factors in the ovaries. Failure to ovulate due to decreased ovarian function can lead to decreased fertility and infertility. Due to individual differences, some patients with premature ovarian failure do not have complete loss of ovarian function, but have a short period of time to restore normal ovarian function, so intermittent ovulation can occur, and when the time is right for sex, sperm-egg union can occur, and some patients with premature ovarian failure can conceive naturally. For women with high-risk factors, it is recommended that they have children as soon as possible while their ovaries are functioning normally to avoid the trouble caused by declining ovarian function. For those who cannot conceive naturally, the fertility department will usually provide endocrine support and a microenvironment for follicular development to promote the development of follicles and their discharge to help conception, or use egg donation to help patients achieve their fertility requirements. Therefore, not all patients with premature ovarian failure are unable to conceive naturally. For those who are unable to conceive, treatment and management, together with assisted reproduction techniques, can help them to fulfill their fertility wishes.