Menopause is a physiological process that every woman must face during the course of her life. Menopause indicates the decline of ovarian function and the end of reproductive capacity. Menopause is defined as the complete cessation of menstruation for more than 1 year. The age of menopause varies from region to region and from one ethnic group to another. For example, the average age of menopause is 52 years for European and American women and 48 years for African women, while the average age of menopause is 49.5 years for Chinese urban women and 47.5 years for rural women. In addition, the age of menopause may also be related to the environment, local climate, and one’s own condition. menopause before the age of 40 due to ovarian decline is called premature ovarian failure, and this condition is pathological. The menopausal transition is mostly gradual, and during this process, if there is a series of symptoms caused by a decrease in sex hormones, it is called perimenopausal syndrome. If the symptoms are more obvious, hormone replacement therapy can be applied, and hormone replacement can prevent cardiovascular diseases or osteoporosis, etc. However, it is important to first exclude contraindications to hormone replacement during gynecological examination, and then provide targeted and individualized treatment according to your situation, as well as regular follow-ups. In conclusion, the age of menopause varies greatly among women due to individual differences, with most menopause occurring around the age of 49.