The 13-valent vaccine usually refers to the 13-valent pneumococcal polysaccharide conjugate vaccine, which can prevent 13 types of pneumococcal infections. According to the National Center for Disease Control and Prevention, the 13-valent pneumococcal polysaccharide conjugate vaccine is restricted to children from 2 weeks of age to 15 months of age and can be given at any time of the year.1. Vaccination schedule: There are four doses of 13-valent pneumococcal polysaccharide conjugate vaccine, the earliest of which can be given at 2 weeks of age, with each subsequent dose given at an interval of about 4-8 weeks, and the last dose given at 12-15 months of age. The last dose will be given at 12-15 months of age, and the interval between the fourth and third doses should be more than 8 weeks. Premature babies need to be vaccinated according to their actual age, i.e., they can be vaccinated after their actual age at birth reaches 2 weeks; 2. People who should not be vaccinated: Those who are allergic to 13-valent pneumococcal polysaccharide conjugate vaccine components, excipients or diphtheria toxoid should not be vaccinated at any time. People with acute illness or fever need to be vaccinated after the illness is cured. Cross-vaccination is also not recommended if the vaccination period is during other vaccination periods, and 13-valent pneumococcal polysaccharide conjugate vaccination should be administered after the completion of other vaccination procedures; 3. Caution: 13-valent pneumococcal polysaccharide conjugate vaccine cannot be administered intramuscularly or intravenously in the buttocks, which may cause adverse reactions and affect the vaccine effect. After vaccination, close observation is required for any serious allergic reactions or adverse reactions to the vaccine, and any respiratory difficulties should be sent to the hospital as soon as possible.