If patients with renal tumor lose the chance of surgery due to metastasis, they can have symptomatic hemostasis and pain relief treatment; if it is clear cell carcinoma, they can also be treated with targeted drugs; if they can not tolerate the trauma of surgery due to cardiorespiratory insufficiency, they can adjust their cardiorespiratory function to stabilize and then have surgery. 1. Patients with advanced tumor: advanced renal tumor with multiple metastases in the whole body, which has lost the significance of surgical treatment, can be treated with hemostasis, pain relief and nutritional support. For example, tumor blood vessel embolization can stop bleeding, use pethidine hydrochloride for pain relief and other treatments to improve patients’ survival quality. If it is renal clear cell carcinoma patients can consider using targeted drug therapy such as sunitinib, and immunotherapy can also be used. 2. Patients with cardiopulmonary insufficiency: patients who cannot be operated due to other organs’ insufficiency can have their organs’ functions regulated first, and then undergo surgical treatment when their physical conditions can tolerate the surgery. In conclusion, when kidney tumor is inoperable, we should combine the reasons of inoperable patients and carry out targeted treatment under the guidance of professional doctors.