Painful Ocular Muscle Paralysis Syndrome can be recovered, with mild symptoms resolving on their own, and severe cases recovering with medication. PEMS is a self-limiting disease that resolves spontaneously in about 30% to 40% of patients. In severe cases, medication is needed. Glucocorticoids are commonly used to suppress the inflammatory response and improve eye pain and eye movement disorders. At the initial stage, large doses can be administered intravenously, and the dose can be reduced after the condition improves, and then gradually changed to oral or discontinued. If there is painful ophthalmoplegia syndrome, it is recommended to seek medical attention as soon as possible, part of the although it can be self-cured, but some patients do not have timely treatment in the early stage, can lead to blindness and meningitis and other complications, the drug should be prescribed by a doctor for reasonable application.