The specific cause of chest tightness and shortness of breath at night should be clarified and targeted treatment should be taken according to the specific cause. If a young person has chest tightness and shortness of breath at night, the possibility of an acute attack of bronchial asthma should be considered. Bronchodilators can be used for relief, such as albuterol sulfate aerosol or doxorubicin for treatment. There is a possibility of spontaneous pneumothorax, which needs to be treated by thoracentesis or closed chest drainage. If an elderly person has chest tightness and shortness of breath at night, it is necessary to consider the possibility of an acute attack of chronic cardiac insufficiency, and it is necessary to improve the electrocardiogram and cardiac ultrasound as soon as possible for clarification, and to give diuretic, vasodilator and cardiotonic treatment.