Atrophic gastritis with intestinalization, i.e. chronic atrophic gastritis accompanied by intestinal epithelial biochemistry, mainly refers to the chronic inflammatory damage to the gastric mucosa, resulting in epithelial atrophy and glandular reduction, and the gradual replacement of gastric mucosal epithelial cells by epithelial tissue in the large or small intestine. Patients need prompt medical attention, regular treatment, and regular review. The clinical manifestations of atrophic gastritis with intestinalization may not be consistent with the progression of the disease to some extent. Some patients may have no obvious symptoms, but most patients may have indigestion symptoms such as vague pain, burning, and a feeling of fullness in the upper abdomen that worsen after eating. In more severe cases, physical wasting, anemia, and upper gastrointestinal bleeding may also occur. Treatment and care generally requires medication, which can be used under the guidance of a medical professional to inhibit gastric acid secretion and promote gastrointestinal motility. If the abdominal pain is obvious, antiemetic and analgesic drugs can be used as appropriate to improve the gastrointestinal discomfort. If H. pylori infection is present, it can also be treated with quadruple drugs under the guidance of a doctor. Alcohol should be avoided in daily life and a light, low-salt diet should be taken to reduce the irritation of the gastric mucosa and slow down the development of the disease.