Immune system diseases include many, such as SLE, vitiligo and ankylosing spondylitis, etc. Therefore, it is necessary to determine whether the New Crown vaccine can be administered according to the classification, severity and clinical manifestations of the disease, etc. The vaccination can be administered if the disease is in a stable state and the condition of the disease is good, but otherwise it is not recommended. Before vaccination for immune system diseases, a comprehensive health examination should be done to make sure that the disease is in a stable state with no adverse reactions or complications, and that the vaccination is approved by the attending physician before the vaccination is administered. Since most patients with immune system disorders require long-term medication to control their disease, if they are on medication, they can consult with their doctor if they need to stop taking the medication for a period of time before receiving the New Crown vaccine. In addition to those with immune system diseases, patients with other chronic diseases such as hypertension and diabetes, those who are preparing for pregnancy, and nursing mothers should also be selectively vaccinated. Pregnant women, patients with allergies to vaccine components, patients with acute diseases, patients with chronic disease episodes, and patients with mental illnesses should not receive the New Crown vaccine.