A headache when you stay up late, excluding organic diseases, generally because the neck and shoulder, head muscles in a long-term tension, causing soft tissue edema, compression of peripheral nerves caused by the long-term continuous stay up late will have the risk of sudden death. Continuous staying up late can increase the burden on the cardiovascular system, leading to heart rhythm disturbances, such as frequent premature beats, paroxysmal supraventricular tachycardia and other arrhythmias, increasing the burden and load on the heart, increasing the possibility of sudden death. Long-term late night can also affect the neurohumoral endocrine system, such as the renin-angiotensin-aldosterone system system is easily activated, there will be unstable blood pressure and other situations, therefore increasing the chance of sudden death. In addition, long-term late night can also lead to sympathetic hyperexcitation, increased cardiac work, cardiac perfusion deficit, increasing the risk of sudden death. Staying up late can also lead to a decline in immunity, poor skin, affect fertility, and increase the prevalence of chronic diseases, so you must work regularly and try to avoid staying up late.