Acne is a disease that is prone to recurrence and has an aesthetic impact with mild and severe ups and downs. The treatment of acne should be individualized according to different causes, different types, different severity and the patient’s skin characteristics to choose the appropriate treatment plan. The general treatment principles are: combining Chinese and Western medicine, and treating both inside and outside. First of all, we should clarify the purpose of acne treatment: to reduce symptoms, prevent recurrence, and prevent scar formation. At present, the main treatments for acne are sebum suppressing drugs, anti-keratinization, anti-bacterial and anti-inflammatory treatments, and so on. According to the different types of Chinese medicine, there are prescriptions for clearing heat and detoxifying, dispelling dampness and phlegm, nourishing Yin and invigorating blood, clearing heat and draining the liver, draining pus and swelling, and softening and dispersing knots. Some patients with mild cases can be treated with topical medication alone; those with severe cases often need a combination of oral medication and topical medication; some patients with recurrent attacks need a combination of Chinese and Western medicine; some patients with “acne marks” and “acne scars” need herbal masks, photorejuvenation, fractional laser and other treatments. Some patients with “acne marks” and “acne scars” need herbal masks, photorejuvenation, fractional laser, etc. Therefore, for each patient, an individualized treatment plan should be formulated, combining Chinese and Western medicine, and treating both inside and outside in order to achieve the most ideal results.