Usually, methylprednisolone tablets do not have to be taken on an empty stomach. Since methylprednisolone tablets are glucocorticoids, they can be taken orally at 7-8 am in the morning for the treatment of connective tissue diseases such as systemic lupus erythematosus, rheumatoid arthritis, dermatomyositis, or nephrotic syndrome, but there are no strict rules on whether to take them on an empty stomach. The dosage may vary from disease to disease. Generally speaking, glucocorticosteroids are stimulating to the gastric mucosa and may cause stomach pain, heartburn and other symptoms, and may increase the risk of bleeding from the gastric mucosa. However, there are a few patients in the acute phase of inflammation, in order to increase the degree of drug absorption, it is necessary to take methylprednisolone tablets before meals. If you have gastrointestinal discomfort when taking on an empty stomach, you can give feedback to your doctor for medication adjustment. The peak of glucocorticoid secretion is in the early morning and the trough is at midnight. When glucocorticoids reach a low point, the body will produce glucocorticoid-producing hormones. Therefore, taking methylprednisolone tablets at 7-8 am can make the exogenous glucocorticoids provided in the drug, and the body’s own endogenous glucocorticoid rhythm get overlapped, so as to maximize the effect of the drug and enhance the effect of promoting inflammation absorption. The metabolism time of methylprednisolone Tablets is similar to that of endogenous glucocorticoids, and taking it early in the morning can mimic the effect of endogenous glucocorticoids without affecting the normal production of glucocorticoids in the body. Methylprednisolone Tablets should be applied, discontinued or reduced in accordance with medical advice and should not be changed at will. If the symptoms of the disease worsen while taking it, or if there are obvious adverse drug reactions, you should promptly give feedback to your treating doctor and change or reduce the dosage under the guidance of your doctor.