It is an autoimmune disease mainly invading salivary glands and lacrimal glands. It not only appears dry mouth and dry eyes, but also invades many organs of the whole body and produces various clinical manifestations. Clinical manifestations】 1.Dry mouth: saliva secretion decreases, severe cases need to drink water frequently, sometimes need to get up to drink water at night, and need to send down with water when eating cookies, steamed bread and other solid food; teeth gradually become black, caries appears, then small pieces fall off, and finally only residual roots remain, becoming rampant dental caries; there may be tongue pain, dry and cracked tongue, and atrophy of tongue papilla. 2.Dry eyes: reduced tear secretion, dry eyes, gritty and burning sensation, more eye droppings, fear of light, less tears, even no tears when crying, and may appear keratitis or conjunctivitis. 3, parotitis: 50% of patients present with intermittent parotid swelling and pain unilaterally or bilaterally. If persistent parotid enlargement is present, the transformation into lymphoma should be alerted. 4. Dry and itchy skin, dry nasal cavity, dry throat, hoarseness, dry, itchy and easily infected vulva. 5. Systemic manifestations: malaise, hypothermia, a few hyperthermia, arthralgia, leukopenia, thrombocytopenia, purpura-like rash on both lower limbs, atrophic gastritis, chronic diarrhea, hepatic impairment, hypokalemic muscle paralysis weakness due to renal tubular acidosis, interstitial pneumonia, pulmonary alveoli, sensory and motor nerve abnormalities, and primary biliary cirrhosis may be combined. Ancillary tests] Most patients have positive ANA, anti-SSA antibody, anti-SSB antibody, rheumatoid factor, elevated immunoglobulin, tear secretion test, oral saliva flow rate, and lip gland biopsy are all beneficial to the diagnosis of SS. How to treat】 1.Replacement and symptomatic treatment: dry mouth requires more water, stimulation of salivary gland secretion with cyclopentethione, etc., and dry eyes with artificial tears. 2. In case of systemic damage, glucocorticoids combined with immunosuppressants can be applied, and oral potassium citrate is required in case of hypokalemia. Precautions] 1, SS patients are easily depressed, usually need to keep a happy mood, avoid mental stimulation and impatience, ensure sleep, avoid overwork; maintain a suitable indoor temperature and humidity, prevent respiratory tract infections. 2, develop the habit of rinsing mouth or brushing teeth after meals to prevent oral infection and dental caries, often contain plum, Tibetan green fruit, chew chewing gum, use white chrysanthemum, honeysuckle, umeboshi licorice soup as a substitute for tea, eat more nourishing and heat-clearing foods, such as loofah, celery, yellow cauliflower, lotus root, yam, salvia, watermelon, pear, orange and orange, etc.; prohibit smoking and alcohol, avoid spicy, fried, warm food.