Grape seeds are the seeds of grapes, which can also be processed and extracted into commercially available grape seed-based health products, which may have certain hazards when taken for a long time. I. Seeds of grapes: Although they contain vitamins, amino acids, trace elements and minerals, etc., the digestible nutrients are minimal, and the following hazards may also occur when taken directly by mouth for a long period of time.1. Mucosal damage: They may cause damage to the mucosa of the digestive tract, as grape seeds may have relatively sharp parts that can scratch the mucosa of the gastrointestinal tract, causing pain, bleeding and inflammatory reactions.2. Affecting appetite: Grape seeds contain a large amount of tannins, which can coagulate proteins on the surface of the lips, mouth and esophagus, causing saliva to lose its lubricity, which can produce an astringent taste and lead to a decrease in appetite; 3. Risk of foreign bodies in the trachea: they may get stuck in the trachea, which may cause breathing difficulties or even life-threatening if not removed in time. In this case, it is recommended to immediately visit the emergency department or ENT department of a hospital to remove the grape seeds. Second, processed grape seeds: not suitable for long-term use, may affect health and some adverse reactions. 1, dizziness: grape seed extract can lower blood lipids, lower blood pressure and inhibit thrombosis, but when blood pressure is low, long-term use of grape seeds may cause dizziness. 2, indigestion: people with poor constitution or poor spleen and stomach, long-term use may lead to indigestion. 3, aggravation: grape seeds can maintain capillary permeability, and long-term use by people with bleeding tendencies or coagulation disorders may aggravate the condition. In addition, grape seeds should be used with caution for people who are preparing for pregnancy, pregnant or breastfeeding, and should not be taken by children. In addition, grape seed supplements should be purchased through regular channels and taken according to instructions or medical advice.