There are many reasons for stomach cramps and pain for a few seconds every few minutes, and what medicine to take depends on the cause. If it is a sudden stomach bout of colic, mostly due to dietary factors, abdominal cold caused by strong contraction of the smooth muscle of the gastrointestinal tract, generally by drinking hot water, with abdominal heat can be relieved, serious cases can take antispasmodic drugs. Acute gastritis will also have this symptom, patients often accompanied by obvious vomiting, diarrhea, etc., to timely replenish electrolytes and water, and give gastric mucosa protective agents and acid suppressants, bacterial infection should also be anti-infective treatment. In the case of gastric ulcer, it is necessary to improve the eating pattern, stop taking unnecessary non-steroidal anti-inflammatory drugs, actively eradicate Helicobacter pylori infection, and treat to inhibit gastric acid secretion and protect gastric mucosa according to the patient’s condition. In addition, duodenal ulcers, gastric polyps and stomach tumors may also present this symptom and need to be identified. For patients with gastric bouts of colic, pain for a few seconds every few minutes, it is recommended to promptly consult a gastroenterologist or emergency department for gastroscopy and other tests to clarify the cause.