Otitis media is divided into suppurative otitis media and secretory otitis media. Suppurative otitis media is caused by bacterial infection, and if the otitis media is caused by amoxicillin-sensitive causative bacterial infection, it is effective to take amoxicillin in the absence of drug resistance. Secretory otitis media is not effective on amoxicillin when it is caused solely by structural and functional abnormalities and when no bacterial infection is present. Otitis media caused by bacterial infection, the common causative organisms are pneumococcus, Haemophilus influenzae, hemolytic streptococcus, etc. If systemic medication is needed for anti-infective treatment, antibiotics that are sensitive to the causative organisms can be selected according to the results of drug sensitivity tests. Amoxicillin belongs to penicillin antibiotic drugs, commonly used in the above common pathogenic bacteria infections. However, some types of otitis media are caused by dysfunction of the Eustachian tube, such as adenoid hypertrophy in children, poor elasticity of the Eustachian tube cartilage, etc. In this case, surgical treatment is often required, and amoxicillin is generally unable to achieve the purpose of effective treatment. Once the otitis media, you need to go to the hospital in time to find out the cause of the disease, follow the doctor’s instructions to standardize the use of drugs and treatment.