Patient: It is oxaliplatin plus fluorouracil, calcium folinic acid chemotherapy, nausea and vomiting, how can I prevent it? Doctor: Generally speaking, it is very common to have nausea and vomiting with oxaliplatin/fluorouracil/calcium folinic acid chemotherapy, and our general management measures are as follows: First, you should prevent it by giving dexamethasone, diphenhydramine and strong anti-vomiting drugs (such as ondansetron, toltesetron, etc.) 15-30 minutes before chemotherapy; second, you should prescribe some anti-vomiting drugs for the patient. If the patient only feels nausea and left boredom, but no vomiting, then he can take oral gastrofacial, 10 mg each time, 3 times a day; if vomiting occurs, then take oral ondansetron extended-release tablets, 1 tablet each time, 1-2 times a day; the above treatment can usually cope with most of the reactions. If the patient’s reaction is more severe, then strong anti-vomiting drugs (such as ondansetron, toltesetron, etc.) for intravenous use should be continued for 3-5 days after the chemotherapy is finished, which can significantly reduce the reaction. If the above treatment does not control the reaction, then the chemotherapy drug should be reduced or even suspended.