During chemotherapy must ensure personal hygiene. 1, change the underwear regularly 2, gargle regularly: before and after the temporary have to gargle, routinely use sodium bicarbonate solution and tylenol gargle. Large doses of methotrexate during the period should also contain calcium tetrahydrofolate (a few minutes each time) 3, wash the buttocks after defecation, there are erosion or anal fissure, apply Bactroban ointment Public hygiene 1, to keep the room clean, the floor dry 2, hazy days to close the doors and windows 3, the hospital beds do not pile up too many items toys to be disinfected