Oral mucositis (OM) is the most difficult acute side effect to manage after concurrent chemoradiotherapy (CCRT) in head and neck cancer patients (HNC). The pain caused by oral mucositis can interfere with the patient’s oral function and nutrient absorption, which can lead to treatment interruption. Several regimens are available for the prevention and treatment of oral mucositis, but no fully effective treatment regimen has been developed to date. In an article published in the August issue of Radiother Oncol, Gautam AP et al. from India investigated the above issue – prophylactic application of low-dose laser therapy for the prevention and treatment of oral mucositis induced by simultaneous radiotherapy. The study was a triple-blind study that included 221 patients with head and neck tumors who received simultaneous radiotherapy with cis-chloroplatin chemotherapy at days 1, 22, and 43, as well as radiotherapy at a total dose of 66 Gy (a total of 45 sessions of 2 Gy/treatment 5 days per week for a total of 33 sessions). These patients were randomized into a laser therapy group and a placebo group. The laser group received low-dose laser therapy five times a week, as opposed to the placebo group that received placebo before radiotherapy. Assessment metrics included oral mucositis, oral pain, dysphagia, weight loss, and simultaneous radiotherapy intervals. Data were analyzed using frequencies and percentages, generalized estimating equations, and ratio ratios. The results of the study showed that patients in the laser treatment group had a significantly lower incidence of severe stomatitis and its associated pain, dysphagia, and opioid analgesic use than patients in the placebo group, with all differences being statistically significant. The study concludes that low-dose laser reduces severe stomatitis and associated pain, dysphagia, and opioid analgesic use due to concurrent radiotherapy.