This disease is mainly characterized by dark gray spots symmetrically distributed on the zygomatic area. It was once thought to be a variant of nevus of Ota, but in fact, it is different from nevus of Ota in terms of clinical features and histopathology, and some people call it acquired nevus of Ota or Hori’s spot. The disease mostly occurs in women, and the age of onset is mostly 16-40 years old. It is a grayish-brown, dark gray or dark brown pigmented spot with a diameter of about 1-5mm on the face, mostly on the zygomatic area. They are round, oval, with clear boundaries, and the number varies from several to dozens, with an average of 10~20, and most of them are symmetrically distributed bilaterally. For the treatment of the same nevus of Ota, 1064 and 755 laser are commonly used (532 laser is basically useless, 690 laser is similar to 755 laser in terms of effect alone, but the failure rate is very high and not as good as 755 laser, so basically most hospitals do not choose 690, but 755 laser). Since the 1064 wavelength absorbs only one-third of the 755 wavelength for pigment, the 1064 laser is not as effective as the 755, so relatively speaking, the 755 emerald laser is now recognized as the best by the majority of hospitals. However, for any treatment, the equipment is only part of the factor, but more important is the operator’s technique. Even if the same 755 laser is used, good technology, a treatment to play thoroughly enough, the energy used enough, generally play once the effect can be maintained for a year, that do a twice, two or three times is enough. But if the operation is not skilled, not thorough enough, the energy used is not enough, then generally three months after the ineffective, you have to go back to do it again, then you have to do seven or eight times.