Foliar depigmentation is most often seen in tuberous sclerosis, one of its clinical manifestations, as ovoid, striated, lobulated hypopigmented spots. The disease is autosomal dominant, and disseminated cases are also common. The gene is localized at 9q34 or 16q13.3, a tumor suppressor gene, and the gene products are hamartin and tuberin, respectively, both of which regulate cell growth. What are the preventive treatments for lobar depigmentation? Clinical manifestations and preliminary diagnosis of foliar depigmentation symptoms 1. Skin changes: mainly sebaceous adenoma of the face. 2.Neurological symptoms and signs: manifested as epilepsy and mental retardation. 3.Ocular changes: most commonly optic papillae and retinal nodules. Diagnosis: The diagnosis of sebaceous adenoma, mental retardation and epilepsy can be confirmed by the presence of the three main signs. However, the three main signs do not always appear together in clinical practice. Sebaceous adenoma, which is seen in almost all patients; fundus lesions are often found during ophthalmologic consultations after the diagnosis of sebaceous adenoma is confirmed. There is no specific treatment for this disease. Symptomatic treatment such as seizure control, infantile spasms can be treated with ACTH; application of dehydrating agents to lower intracranial pressure, obstruction of cerebrospinal fluid circulation can be treated surgically, and facial sebaceous adenoma can be treated with cosmetic surgery.