Drugs for treating knee necrosis include non-steroidal anti-inflammatory drugs and nutritive cartilage drugs. 1. Non-steroidal anti-inflammatory drugs: such as ibuprofen, nimesulide, etc., can improve the patient’s knee pain and swelling. 2. Nutritional cartilage drugs: such as glucosamine hydrochloride or glucosamine sulfate, chondroitin sulfate, sodium hyaluronate, etc., which can improve the metabolic function and nutrition of bone and cartilage, and slow down the progress of the disease. All of the above medications should be used in conjunction with your own condition and under the guidance of your doctor. Due to the rich blood flow in the knee joint, the chance of necrosis is usually small, and necrosis in the knee joint usually needs to be treated by surgery. After removing the necrotic tissue, adequate and extensive bone grafting or internal fixation treatment, and if necessary, knee replacement, can completely treat necrosis of the knee joint.