Possible causes of esophageal atresia include high intrauterine pressure, occlusion of the esophageal epithelium, abnormal blood supply to the esophagus, and abnormal growth of local tissue differentiation. Both the esophagus and pharynx are derived from the foregut. Initially, a longitudinal groove appears on the outside of each side of the intestine, and thus two longitudinal ridges appear on the luminal surface of the foregut tube at the corresponding places. As the two longitudinal grooves gradually deepen, the corresponding longitudinal ridges become closer and closer, and eventually converge, dividing the foregut into two tubes, which ventrally become the respiratory tract, and dorsally become the esophagus. The esophagus has two origins, and both the upper part thereof and the upper part of the trachea are derived from the pharynx of the foregut. The esophagus and the lower part of the trachea develop from the gastric part of the foregut. In the fifth to sixth week is the endoderm an epithelial proliferation lumen temporarily occluded, later in the parenchyma tissue appeared many vacuoles, fused with each other again appeared in the official lumen of the penetration, such as esophageal part of the esophagus did not appear vacuoles or vacuoles incomplete formation of the esophageal atresia.