Reduced secretion of antidiuretic hormone (adh) is one of the symptoms of syndrome of inappropriateantidiuretic hormone secretion (SIADH), a 9-peptide hormone secreted by nerve cells in the supraoptic and paraventricular nuclei of the hypothalamus. hormone, which is released after reaching the pituitary gland via the hypothalamic-pituitary bundle. Its main role is to increase the water permeability of the distal convoluted tubules and collecting ducts, promote water absorption, and is a key regulatory hormone for urine concentration and dilution. In addition, the hormone also enhances the permeability of the collecting ducts of the inner medulla to urea. After drinking large amounts of water, blood is diluted, crystal osmolarity decreases, and antidiuretic hormone secretion is reduced. Screening items for reduced secretion of antidiuretic hormone (adh): 1. Doping urine test Doping urine test is an auxiliary test used to check whether an athlete is doping. The reason for this is that metabolites in the human body are generally excreted in the urine. In addition, the urine test is a simple and effective way to detect doping as the sample is not harmful to the body and athletes are happy to accept it. Later, some athletes used doping in order to avoid doping control by taking drugs during normal training and stopping them before the competition. This is because drugs, such as anabolic agents and peptide hormones, have the ability to induce athletes to grow muscle circumference and a variety of other physiological effects and maintain these effects for a considerable period of time after discontinuing the drug. To prevent athletes from doping in this way, international sports have added out-of-competition urine testing since the 1990s, in addition to in-competition urine testing. That is, without prior notice, selected subjects are suddenly tested at any time during the athletes’ usual training time. These tests are always carried out by Olympic officials flying around the world, so they are often called flying tests, commonly known as “flying tests”. This test can determine the corresponding signs of disease. 2.Water load ADH suppression test The water load ADH suppression test is to check whether there is inappropriate secretion of antidiuretic hormone (SLADH), which refers to the abnormal increase in the secretion of antidiuretic hormone (ADH) in the body or its abnormal activity, resulting in water retention, increased urinary sodium excretion and dilutional hyponatremia and other syndromes. Antidiuretic hormone, also known as pressor hormone, is a cyclic peptide hormone secreted by the hypothalamic supraoptic nucleus. Its physiological function is to enhance the reabsorption of water by the distal tubules and collecting ducts of the kidney and play the role of antidiuretic, which can maintain the normal colloid osmotic pressure of plasma and therefore has a great influence on the concentration function of the kidney. Changes in blood volume and blood pressure and other factors can affect the secretion of antidiuretic factor. 4, urine dilution test urine dilution test is a test method to check whether the glomerular acidification function is normal. The principle is that blood dilution after drinking water, plasma osmolality (Posm) decreases, and antidiuretic hormone (ADH) secretion decreases, resulting in a series of changes such as increased urine volume and increased urine volume with decreased urine osmolality (Uosm). 5. Plasma antidiuretic hormone Plasma antidiuretic hormone is a hormone secreted by the hypothalamus and released in the pituitary gland due to water shortage in the human body, which can strengthen the renal tubular reabsorption capacity of water, prevent a large amount of water outflow, play an antidiuretic role, maintain normal plasma colloid osmotic sub, and therefore have a great impact on the concentrated function of the kidney. Changes in factors such as blood volume and blood pressure are ke to affect the secretion of antidiuretic hormone.