The top ten cancers that are difficult to cure, first of all pancreatic cancer, also include bile duct cancer, liver cancer, stomach cancer, breast cancer and cervical cancer and many other cancers with poor prognosis: 1, pancreatic cancer: the title of king of cancer, some studies found that the incidence and mortality rate of pancreatic cancer is close to 1:1. Because of the deep location of the pancreas in the human body, it is often difficult to be detected in the early stage of pancreatic cancer, and even if clinical symptoms of pancreatic cancer are diagnosed, surgery is difficult and the risk of surgery is very high. Even if pancreatic cancer is diagnosed with clinical symptoms, it is difficult to operate and the risk of surgery is also very high. In addition, the cells of pancreatic cancer tend to be more malignant, prone to spread and metastasis, and less sensitive to radiotherapy and chemotherapy, so the prognosis is very bad. 2. The incidence rate of cholangiocarcinoma is relatively low, but usually the malignancy of cholangiocarcinoma is high and the prognosis is also poor. Some post-metastatic cholangiocarcinoma may have lost the chance of surgical treatment after diagnosis. If cholangiocarcinoma has metastasized, surgical treatment will not be ideal, so cholangiocarcinoma is difficult to be cured; 3.hepatocellular carcinoma: China is a large country of hepatocellular carcinoma, because hepatocellular carcinoma itself has strong inhibition, its sensitivity to chemotherapy and radiotherapy is poor, plus many hepatocellular carcinoma patients will have combined viral hepatitis and cirrhosis, so their tolerance to chemotherapy or radiotherapy is poor, especially for short-term hepatocellular carcinoma patients The prognosis is poor; 4. Gastric cancer: in early stage, it often lacks specific digestive symptoms and is easily confused with benign gastric ulcer or chronic gastritis. Early gastric cancer can be treated by surgery, while late gastric cancer is often more malignant and less sensitive to chemotherapy, so the treatment means are relatively single; 5.Breast cancer: breast cancer is a malignant tumor that occurs in the epithelial tissue of the breast. And metastasize to distant organs, causing dysfunction of the organism. The mortality rate of breast cancer in China is very high, and the pathogenesis is not very clear at present, and breast cancer usually leads to death soon if it spreads to other fatal organs, so it is generally considered a more difficult cancer to be cured; 6. Cervical cancer: cervical cancer is the second most common tumor in women, it usually has no symptoms for 5-10 years, so once found It is usually asymptomatic for 5 to 10 years, so once it is detected, it may already be at an advanced stage, which is more difficult to be cured, but if it is detected early through regular medical checkups, the success rate of cure is still very high; 7. It is characterized by unrestricted proliferation of white blood cells in body tissues, infiltration of all organs of the body, and the appearance of infantile white blood cells in the blood circulation, often accompanied by an increase in white blood cells. Clinical symptoms are fever, anemia, bleeding, enlargement of liver, spleen and lymph nodes to different degrees. Due to the decrease of white blood cells and low immunity of leukemia patients, it is usually difficult to be cured; 8. Esophageal cancer: Esophageal cancer can affect eating and vocalization, and even involve trachea and lungs, leading to symptoms of breathing difficulties. It is usually multiple and multi-located, which is difficult to be cured by surgery or radiation therapy; 9. Lung cancer: usually the malignancy of lung cancer is relatively high, and it is very easy to progress and metastasize. Although most small cell lung cancers have a high remission rate during the first treatment, most patients will soon experience recurrence; 10. Colorectal cancer: Colorectal cancer is a common disease threatening human health, and usually the symptoms are not obvious in the early stage, it can spread to other tissues through lymphatic blood circulation and direct spread, resulting in symptoms such as anemia and weight loss, which are more difficult to cure.