We accept the traditional concept and the most commonly encountered situation in the clinic – “soy products should never be eaten” for the following reasons: vegetable protein has low bioavailability and contains more non-essential amino acids, which easily leads to increased production and excretion of nitrogenous substances after intake and increases the burden on the kidneys. Animal proteins, on the other hand, contain more essential amino acids and are highly bioavailable. However, the nutritional value of soy protein is far from ordinary vegetable protein, which is a high biomass value complete protein with a digestibility and absorption rate of 84%-98%. Mixed meals can improve protein utilization, and pairing with staple foods can improve plant protein utilization. High animal protein meals can cause a significant increase in renal blood flow, while soy protein has no significant effect on renal blood flow. The soy isoflavones in soy protein also have antioxidant, lipid-lowering, and blood pressure-lowering effects. Soy protein can be consumed in chronic kidney disease, and although it has many benefits, soy protein intake needs to be limited because of the need to control protein intake in chronic kidney disease.