Hormone is a common clinical drug, renal disease will also be often used, it includes prednisone, dexamethasone, hydrocortisone, prednisolone and so on. However, the side effects of this drug are also very large, the author often encountered some irregular use of this drug caused by patients with pharmacogenetic? harm to patients who come to the clinic. Corticosteroids have anti-inflammatory, anti-toxicity, anti-shock, inhibit immune response and many other medicinal effects, in some acute immune diseases and some chronic immune diseases have a better therapeutic effect, such as systemic lupus erythematosus, nephrotic syndrome and so on. However, it has strict indications and contraindications, and there are strict controls on the dosage and time of use, which is because we must consider the therapeutic effects and side effects of hormones. We use a drug must be more therapeutic than side effects, and the side effects must be non-fatal, the duration of the side effects is as short as possible, the side effects as much as possible is controllable and reversible, we will choose. Otherwise it will bring irreversible damage to the patient. The common side effects of hormones are: 1, decreased resistance, easy to infection, such as lung infection, intestinal infection, secondary infection; 2, wounds do not allow healing, wound leakage; 3, pharmacogenetic obesity (Kirchhoffer’s syndrome); 4, gastrointestinal tract ulcers, bleeding; 5, osteoporosis, necrosis of the femoral head; 6, euphoria and other psychiatric symptoms; 7, pharmacogenetic elevation of blood pressure. Through the above discussion, we must be careful in the use of hormones carefully, can not use as much as possible, must be used must be to the regular hospital to find a physician to look at after the use, but also can discuss with the physician side effects, play a role in reminding the physician is also a mortal, but also because of the busy work of the reasons for the mistakes, of course, we remind the time to be objective, kind, do not let the physician resentment. As a physician, we should also correctly recognize the patient’s reminder, in fact, is to help us make fewer mistakes and errors.