Autologous fat breast augmentation has made thousands of candidates crazy because of its realistic feel, no incision, almost no scar, no interruption of work and study, long-lasting effect, safe material and a series of other advantages, which has made countless flat-chested women immersed in the joy of breast enlargement, and more and more candidates are ready to join the ranks. However, the recent rumors that fat grafting can lead to breast cancer are causing a lot of anxiety, and those who have received fat grafting do not know what to do, while those who are ready to undergo fat augmentation are even more torn. The origin of the matter is a case of breast cancer diagnosed in a patient with autologous fat breast augmentation after surgery, the topic has triggered a lot of discussion among professional doctors, but also mixed with a variety of lay people’s guesses …… then whether fat transplantation will cause breast cancer? In order to answer your doubts, I will focus on the core issue of “whether fat transfer breast augmentation will cause breast cancer”, and address several issues that are currently of great concern to beauty seekers. I will give you an objective analysis and answer based on the current development status and mainstream academic views at home and abroad. 1. For the surgery of liposuction breast augmentation, will the fatty tissue injected into the breast become cancer cells? Or is it possible for people to develop breast cancer within a short period of time? From the embryological point of view, fat and glandular originate from two different germ layers. Malignant tumors that appear in the ectoderm, where the glands belong, can be collectively called cancer, while malignant tumors that appear in the mesoderm, where the fat cells belong, are called sarcomas. Liposarcoma of the breast is very rare, and no cases of liposarcoma after fat grafting for breast augmentation have been reported. In addition, it takes several decades for a typical cancer cell to develop and form a lump, and unlike infectious diseases, the possibility of short-term disease is minimal. In other words, the claim that fat breast augmentation can cause cancer has no theoretical basis and is unscientific. 2. Although the transplanted fat itself will not turn into cancer cells, will it promote other cells to turn into cancer cells? I heard that there is an experiment to confirm that fat transplantation can promote the growth of cancer cells, what is true about this experiment? Can the results of the experiment show that fat breast implants can lead to breast cancer? This question has to start from the basic research, fat as a graft can stimulate the body to produce a variety of local growth factors, and some of the components contained in the transplanted fat tissue will also play a role in the surrounding tissue. International laboratories have observed through animal experiments that transplanted adipose tissue has a promotive effect on cancer cells, and similar experimental results have been obtained by repeating the experiment in China. In this experiment, human cancer cells and human adipose tissue were co-cultured in a non-human environment (e.g., in petri dishes/nude mice) and observed. The results observed were that the addition of fat grafts to the cancer cells resulted in a significant change in the biological properties of the cancer cells, which were more malignant and more aggressive. However, it is very uncritical to conclude from this that fat augmentation can cause cancer. First, the premise of this experiment is that cancer cells and adipose tissue are co-cultured, and “cancer cells” and “adipose tissue” are indispensable. In clinical work, we are dealing with normal patients, and it is obviously unreasonable to inject fat into a patient who is known to have breast cancer, and for patients with breast lumps or suspicious diseases, we need the assistance of oncologists for diagnosis. Secondly, the characteristics that can change tumor cells in in vitro environment are not unique to adipose stem cells. The test method and results were reported a long time ago, and similar changes in biological properties occurred when cancer cells and bone marrow stem cells were co-cultured, indicating that this is not a unique characteristic of adipose stem cells, so there is no need to “demonize” fat transplantation. Secondly, stem cells exist in the body itself, and the stem cells injected into the body are not more dynamic or stronger than the stem cells in the body, so it is obviously not reasonable to consider them as the main factor causing cancer. The experimental study was conducted outside the human environment, and the situation in the human body is much more complicated. In vivo stem cells are regulated by the body, while in vitro experiments lack in vivo regulation, so experimental studies do not reflect the real situation. Therefore, the experiment has limited significance for clinical guidance, and the most valuable evaluation of the safety of fat transplantation should be a multicenter, large sample clinical epidemiological survey. 3.So what is the conclusion of the current clinical investigation? Is there any difference between the incidence of breast cancer in patients with fat augmentation and the incidence of breast cancer in the general population? A percentage of women will eventually develop breast cancer whether their breasts have been injected with fat or not. Therefore, to show whether fat grafting has an effect on the incidence of breast cancer, it is necessary to compare the difference in the incidence of breast cancer between the normal population and fat grafted breast augmentation patients. Many clinical medical centers internationally are trying to do relevant clinical data statistics. And people tend to choose patients who are more susceptible to post-operative breast cancer who are more susceptible to fat grafting, and theoretically it is safer to inject fat in the general patient population if this group of patients are unaffected by fat grafting. During my study abroad at the University of Michigan, I spent a year reviewing and following up more than 2,400 patients who had undergone breast reconstruction after breast cancer surgery, all of whom had received fat injections, and finally only some of these patients’ data were retained for statistical analysis at the request of statistical experts, and the results showed that fat grafting does not lead to recurrence or metastasis of breast cancer. The results of the corresponding study have been published in Plastic and Reconstructive Surgey, PRS, a leading plastic surgery journal. Many international medical centers have done similar clinical studies and have come to the same conclusion. That is, the results of the current study did not find a difference between the two. 4, since many clinical studies have not observed evidence that fat grafting can cause cancer, why not just announce the authoritative conclusion that fat grafting does not cause breast cancer? The authoritative conclusion in medicine is often based on a large number of studies and takes a long time to reach. For example, the FDA’s safety evaluation of breast implants involved a 10-year follow-up of 100,000 patients before an authoritative conclusion was finally reached. Therefore, even though no current clinical investigations have observed that fat grafting can promote the development of breast cancer, we are unable to draw definitive conclusions for the time being. In the future, an authoritative institution or organization will speak out and give a scientific and reasonable explanation by integrating the existing research results. 5.Some people say that fat grafting can affect the diagnosis of breast cancer. This claim has been around for a long time, but the fact that someone is still asking the same question doesn’t seem very understandable. As you know, the American Society of Plastic Surgeons (ASPS) formed a Fat Graft Task Force in 2009 and issued an authoritative report on diagnostic imaging after breast fat grafting, which showed no evidence to confirm that fat grafting affects the diagnosis of breast cancer on imaging. Imaging physicians believe that the available imaging tools can effectively differentiate between a mass caused by fat grafting and a breast cancer mass; moreover, biopsy can provide a definitive diagnosis if necessary. This view has also reached a wide consensus in academic circles. By analyzing and answering the above points, I believe we can already conclude that there is no evidence that fat grafting can cause breast cancer. Therefore, MM who have had fat augmentation do not need to worry, and MM who are on their way to beauty can continue to move forward. However, these rumors or experiments also remind us that we should choose a regular hospital for fat augmentation surgery, find a plastic surgeon with relevant experience, and undergo a series of breast examinations before the surgery to rule out any pre-existing breast diseases.