1, first find the cause, find is “secondary”, can not find is “primary”. The secondary ones mostly have systemic symptoms, such as pulmonary hypertension. If there is scleroderma, it is easy to be accompanied by ulcers on the fingertips. The primary is relatively good, can be a long time only the hands are afraid of cold, often a white, a burst of purple, and no internal organs involved. 2, found to have Raynaud’s phenomenon, check the antinuclear antibody, perinuclear microcirculation, both are good, the condition is relatively good. Anti-nuclear antibody negative, do not rush to use immunosuppressants, there is a clear autoantibodies, and then targeted with. 3, vasodilator therapy. Calcium antagonists such as nifedipine, as well as ACEI/ARB, alpha-blockers, etc. have a certain role. 4, endothelin receptor antagonists such as bosentan, phosphodiesterase inhibitors have a certain role. Bosentan has been studied to have a clear effect on ischemic finger ulcers in systemic sclerosis. 5, Topical nitroglycerin 6, Antioxidants. There is evidence that antioxidants can improve vascular damage. Some studies suggest that topical application of vitamin E gel can improve finger ulcers. 7, Chinese medicine. Chinese herbs are effective when taken internally and externally. 8, exercise. Exercise is actually very important, hands with Raynaud’s hands should often move. Frostbite, Raynaud’s phenomenon are vascular out of the problem, move more, promote blood circulation, will have an effect.