Raynaud’s phenomenon is a disorder characterized by pale, bruised and then flushed skin on the ends of the limbs. It was first reported by Dr. Raynaud, who gave it its name. It is a vascular pathology caused by intermittent spasm and narrowing of the lumen of small peripheral arteries. In winter, due to the stimulation of cold, so many diseases will exhibit Raynaud’s phenomenon. 1, rheumatic immune diseases Almost all connective tissue diseases can be accompanied by Raynaud’s phenomenon, and can appear before other manifestations of connective tissue diseases. Such as systemic sclerosis, mixed connective tissue disease, systemic lupus erythematosus, rheumatoid arthritis, dermatomyositis and dry syndrome, etc.. Vascular lesions in these diseases are predominantly spastic in the early stages, and after repeated episodes cause inflammation of the arterial wall, which leads to thrombosis and lumen occlusion, eventually leading to tissue necrosis and ulceration. 2, occlusive arterial diseases such as chronic occlusive arteriosclerosis, thrombo-occlusive vasculitis, arterial embolism, etc. 3, neurological diseases including central and peripheral nervous system diseases, such as suboptic thalamic tumors, spinal cord tumors, myelitis and nerve injury, etc. 4, drug-related factors such as ergot and other antispasmodics, beta-blockers, contraceptives, cyclosporine, heavy metal salts and discontinuation of nitroglycerin, etc. 5, occupational factors such as repeated vibratory damage (vibration disease), small fish intermittent hammer syndrome (ulcerative arterial thrombosis). Commonly found in cast iron workers, mechanics, stone workers, typists, pianists, etc. It also occurs due to direct damage to arteries, cold injury and exposure to vinyl chloride at work. 6.Hematological system diseases such as hyperglobulinemia, cold agglutininemia and cold globulinemia, etc. 7.Endocrine diseases such as hypothyroidism, etc. 8, other such as chronic renal failure, malignancy and pulmonary hypertension. In short, Raynaud’s phenomenon is common in rheumatic immune diseases, among which systemic sclerosis, mixed connective tissue disease, systemic lupus erythematosus and rheumatoid arthritis are the most common. In daily life, if Raynaud’s phenomenon occurs, you should first visit the Rheumatology and Immunology Department, so as to make early diagnosis and early treatment.