Clinically, the common causes of pain in the thumb upon bending after waking up from sleep are local pressure, stenosing tenosynovitis, gouty arthritis, and overexertion. The main treatment is pain relief treatment, but also need to be targeted according to the different causes of the above symptoms. 1, local pressure: due to improper posture of the thumb during sleep pressure, resulting in local tissue ischemia, causing pain after waking up thumb bending, treatment is mainly local hot compress, massage treatment, the pain is serious, with pain medication, commonly used pain medication such as celecoxib capsules. 2, stenosing tenosynovitis: due to overexertion, cold and other reasons, resulting in tenosynovitis of the flexor tendon of the thumb, there will be pain when the thumb is bent after waking up. Treatment is mainly local heat, baked electric physiotherapy, and local closure therapy if necessary. If conservative treatment is ineffective, it is often necessary to perform tenosynovial decompression and release treatment under surgery; 3, gouty arthritis: long-term high purine diet will lead to gout attacks, uric acid crystals deposited in the thumb joint, which will cause local edema and inflammation, resulting in pain when the thumb is bent after waking up. The main treatment is pain relief therapy and uric acid lowering therapy. Commonly used pain relief drugs include ibuprofen extended-release capsules and loxoprofen sodium capsules, etc. Commonly used uric acid lowering drugs include febuxostat and benzbromarone, etc. The diet should also be strictly controlled in general; 4. Overexertion: As the hands are engaged in strenuous labor during the day, resulting in local tissue strain, the strain is not fully recovered after sleeping and resting, resulting in pain when the thumb is bent after waking up pain. Treatment is based on local hot compresses, baking electric physiotherapy, and with massage therapy, and can be treated with local application of pain-relieving ointment, commonly used ointment is Furtaline. In daily life, avoid trauma to the hand, if you wake up with pain in the thumb, please go to the hospital for treatment.