The average age of natural menopause in Chinese women is around 50 years old. Natural menopause is defined as the permanent cessation of menstruation due to loss of follicular activity in the ovaries, except for obvious pathological or physiological reasons, and is clinically manifested as the absence of menstruation for 12 consecutive months. Most women enter menopause between the ages of 40 and 55, and women with natural menopause have a transitional period of about one year before their last menstrual period when their menstruation changes or becomes disrupted. Perimenopause or menopause is the period between the start of menstrual changes and one year after the last menopause. Since menopause includes premenopause, menopause, and postmenopause, which can be confusing, the WHO recommended in 1994 that perimenopause be abolished, but it is still used today because it has been used for a long time and is easy to understand. In 1988, the results of a survey conducted by the National Perimenopausal Women’s Health Survey Cooperative Group on 6176 women aged 40-60 years in 10 provinces and 2 municipalities directly under the central government in China showed that the average age of natural menopause in Chinese women was 49 years, and 95.8% of women had menopause between the ages of 40 and 55 years, while only 3.1% had menopause before the age of 40 and 1.1% had menopause after the age of 55 years. However, foreign surveys show that the age of menopause tends to be slowly postponed. The current criteria for determining natural menopause in China are shown in Table 1. Menopausal status associated with tumor treatment is related to ethnicity and various external factors, especially amenorrhea occurs during tumor treatment, and how to determine the menopausal status of these patients is an urgent clinical issue. For example, chemotherapy-induced amenorrhea is not irreversible and is influenced by the type of drug and age. In women <40 years of age, most chemotherapy-induced amenorrhea is reversible, whereas those >40 years of age have a higher chance of transitioning to menopause. There are many clinical cases of long-standing amenorrhea with multiple hormone measurements of menopausal status, but menstruation occurs after AI application. Since the age of menopause in Chinese women may be 10 years earlier than the Western definition of 60 years, experts have reached a consensus on the determination of menopause associated with breast cancer treatment based on the menstrual characteristics of Chinese women. Age, post-treatment amenorrhea, E2 and FSH levels are considered to be the most important indicators of menstrual status, while pre-menstrual status, type of chemotherapy drugs and genetics are important auxiliary indicators. The criteria for determining permanent menopause due to loss of ovarian function are shown in Table 2. In the determination, the age of some individuals can be adjusted individually by referring to the average age of menopause of women in the patient’s family. The recommended clinical interval for hormone testing is >1 month, and the reference values for menopause are, in principle, FSH >40 U/L and E2 <110 pmol/L or 30 pg/mL (conversion factor of 3.67). Since the testing instruments and methods used by each unit are different, it is recommended to refer to the postmenopausal reference value range specified by the measuring unit.