1. What is a “brain pacemaker”? ”Pacemaker” is also known as “deep brain electrode stimulation” in medical science. It is a major breakthrough in the surgical treatment of Parkinson’s disease in recent years and is now recognized by the medical community as an effective treatment option for Parkinson’s disease. The symptoms of Parkinson’s disease occur due to a decrease in the production of dopamine by nerve cells in the brain called substantia nigra. Dopamine is a neurotransmitter through which structures in the brain associated with movement transmit information and control the body’s movements. Due to the decrease in dopamine, some structures in the brain associated with movement (nucleus accumbens, pallidum) are overexcited and transmit abnormal signals, producing the symptoms of Parkinson’s disease. ”By sending a weak electric current, the pacemaker stimulates the nerves that control movement in the brain and suppresses the abnormal brain signals that cause Parkinson’s disease symptoms, thus eliminating the symptoms of Parkinson’s disease and restoring the patient’s ability to live and care for himself. The “brain pacemaker” consists of a compact microelectronic device, including an electrode, an extension lead, and a microcomputer pulse generator (Figure 1). All of these components are implanted in the body. The implanted components do not cause rejection and do not affect the patient’s daily life. 2. Which patients are suitable for the “brain pacemaker”? (1) Patients with primary Parkinson’s disease; (2) Patients with good efficacy of levodopa; (3) Patients whose drug efficacy has gradually decreased or side effects have appeared; (4) Patients who can no longer maintain normal life, work and social activities; (5) Patients who have no obvious intellectual impairment and are willing and able to cooperate during the implantation process and subsequent review. 3.What is the therapeutic effect of “brain pacemaker”? Since the 1990s, with the help of pacemakers, tens of thousands of Parkinson’s disease patients around the world have been able to start a new life, with long-term stable effects: (1) control the main symptoms of Parkinson’s disease: tremor, rigidity, slow or no movement, balance disorders, etc.; (2) reduce the dose of drugs; (3) eliminate or reduce the side effects caused by drugs; (4) eliminate or reduce the side effects caused by drugs; (5) have no significant intellectual impairment, and are willing to cooperate in the process and subsequent review. (4) increase the “on” time, improve the “off” quality of life, and improve the ability to perform daily activities; (5) according to the patient’s condition, non-invasive in vitro adjustments can be made for long-term symptom control; (6) simultaneous bilateral implantation is possible to control (6) Bilateral implantation is possible to control bilateral symptoms, especially midline symptoms such as rising, walking, turning and rolling. The major advantage of installing a pacemaker is that the damage to the brain tissue during the operation is minimal, the operation is reversible, the position of the electrodes can be adjusted to achieve the best effect, and there are few complications. Moreover, the electrodes can be implanted bilaterally to improve systemic symptoms. From the technical point of view, the positioning method of installing “brain pacemaker” is exactly the same as that of disfiguring surgery, and we are fully confident of the accuracy of installing “brain pacemaker” based on the successful completion of more than 1,000 Parkinson’s disease surgeries. However, not many patients in China have been fitted with pacemakers yet, because the implanted electrodes are expensive and the stimulation parameters have to be adjusted repeatedly for about six months after the surgery. Therefore, we will consider all the factors and consult the patient to make the most suitable surgery plan. 5.What are the side effects and complications of the “pacemaker” procedure? ”Pacemakers are a new type of treatment, and their high degree of safety is a major advantage. There are very few permanent side effects, but a very small number of patients feel a loss of muscle strength, a decrease in speech pitch, transient dizziness and transient numbness.