Chinese medicine believes that the kidneys are the root of the innate nature. The Ming Dynasty physician Li Zhongzi’s “The Essential Readings of the Medical Sections” says, “Without this body, there are two kidneys first, so the kidneys are the source of the internal organs, the root of the twelve veins, the source of breathing, and the source of the three jiao.” It shows that the kidney is the beginning of human growth and development, and is the origin of the functional activities of the internal organs. In terms of physiological functions, the kidneys store essence, and essence is the origin of the human body, as stated in Su Wen Jin Kui Zhen Shu, “The essence is the essence of the body.” The “Rhinoceros Candle on the Origin of Miscellaneous Diseases” says, “The source of blood is in the kidney”; the “Treatise on the Origin of Diseases” points out that “the kidney collects essence, and essence is the source of blood” and so on. It is suggested that the vital energy and blood of the human body are produced by the kidney essence, and the kidney essence is the origin of life.　The kidney is the master of bone and marrow. The Su Wen – Pulse to the Essence says “Bone is the house of marrow.” The normal function of the kidney is conducive to strong bones and full marrow. The kidney collects essence, which can be transformed into qi, or kidney qi, which is divided into yin and yang. The kidney is the main growth and development, in the five elements is water, water should be full, can not be withered, nourishing water as the main law; spleen and stomach is the origin of the latter, the source of Qi and blood biochemical, successive heaven can be mutually gifted, mutual influence. If the disease is prolonged and the kidney is affected, it often leads to weakness of kidney qi, void of marrow, loss of kidney essence and inability to transform blood, which inevitably leads to weakness of qi and blood, and even yin deficiency and yang, yang deficiency or yin and yang deficiency. Thus, for patients with blood deficiency with low bone marrow hematopoiesis, the purpose of tonifying the marrow and generating blood is achieved by tonifying the kidney, nourishing yin or yang. Because the clinical manifestations of MDS commonly include fatigue, laziness, dizziness, palpitation, shortness of breath, drowsiness, pallor, and other symptoms of deficiency of both blood and qi, as well as symptoms of low fever in the afternoon or irritability of the five hearts, epistaxis, epistaxis, skin petechiae, hypochondriacal lumps, pale tongue with thin white fur, and weak or fine pulse, the disease is classified according to the patient’s symptoms. Therefore, according to the patient’s symptoms, the disease is classified as “deficiency labor”, “blood evidence” and “Y accumulation”. At present, after the “Workshop on Standardization of Chinese Medicine Nomenclature for Common Blood Disorders” held by the Hematology Committee of the Chinese Society of Integrative Medicine, the Chinese medicine name for MDS was proposed as “Marrow Toxic Labor”. The name of MDS in Chinese medicine was proposed after the “Workshop on Standardization of Chinese Medicine Nomenclature for Common Blood Disorders” held by the Committee of Hematology of Chinese Society of Integrative Medicine. In view of the fact that the TCM syndromes of MDS are characterized by weakness, shortness of breath, pallor, fever, and bleeding, it can be concluded that the pathogenesis of MDS is due to the deficiency of vital energy in the body, and then poisonous evil, which is embedded in the essence, blood and bone marrow, causing stasis due to poison, and poison and stasis blocking each other, resulting in the failure of the biochemistry of essence and blood. Mutual obstruction, loss of essence and blood biochemistry, resulting in a deficiency of essence and blood, weakness of form and qi, and the appearance of deficiency and loss. The pathological mechanism is characterized by a mixture of deficiency and actuality, with the evil being real and the positive being deficient, with the evil toxin stagnation as the root and throughout the disease, and the loss of positive energy as the symptom. We use Qing Huang San to detoxify the toxins, remove stasis and generate blood to improve normal blood production in the bone marrow. Qing Huang San is composed of Xiong Huang and Qing Dai, and Xiong Huang, Arsenic and Arsenicum are the main ingredients of arsenic-containing Chinese medicine preparations. s4S4), pungent, bitter, warm, toxic, belongs to the heart, liver and stomach meridian, has the function of detoxifying and killing insects, drying dampness and dispelling phlegm, and intercepting malaria. Qing Dai, salty, cold in nature, belongs to the liver and kidney meridian, has the function of clearing heat and detoxifying, cooling blood and eliminating spots, and clearing liver and fire, and its active ingredient, indigo red, has antibacterial and antitumor effects according to modern research. The two drugs are complementary to each other, increasing the detoxification efficacy while using cold and heat as a complementary system to restrain and reduce each other’s toxicity, which can make the overall drug properties tend to be calm. The formula has the effect of detoxifying and resolving blood stasis. In addition to Qing Huang San, the treatment is based on tonifying the kidney and filling the essence, strengthening the spleen and benefiting the qi, with the addition and subtraction of the evidence, and the maintenance treatment with western medicine Stanozolol or testosterone undecanoate. In the whole treatment plan, Qing Huang San is like the leader of the monarch, which is in charge of all the medicines, reaching the bone marrow, resolving blood stasis and opening the channels, expelling the evil and pushing out the old to create conditions for the soup to benefit the qi and tonify the blood. The remarkable clinical efficacy also shows the effectiveness of this program. The treatment of MDS with arsenic-based Qing Huang San has achieved positive clinical efficacy. “It is characterized by deficiency of qi, blood, yin and yang, and has the characteristics of mixed deficiency and actuality. Stasis is the real evil, so Qing Huang San is used to detoxify and remove the stasis to obtain the effect. We have treated the cases in 2006 (31 cases), 200 (55 cases) in 2006, (55 cases) in 2008, (12 cases) in 2011 4 cases), 2012 (30 cases of MD S-RAEB long-term survival) have continuously reported the efficacy of Qing Huang San + Spleen and Kidney tonics-based combination treatment of MD The efficacy results of MD S with definite clinical efficacy.