Congenital biliary atresia is a rare and severe jaundice in the neonatal period and is the most common cause of obstructive jaundice in newborns. According to the site of atresia, it is mainly divided into intrahepatic, extrahepatic and mixed types. Extrahepatic biliary atresia is the most common. Congenital biliary atresia is mostly seen in term babies, which are often treated as normal babies at 1-2 weeks after birth, and most of them have no abnormalities and normal stool color. The main symptoms are as follows: 1. Jaundice: The typical manifestation is obstructive jaundice. It is usually revealed gradually in the first 2-3 weeks after birth, and in some cases it appears in the first few days after birth and is often treated as physiological jaundice. The sclera is brown, the skin changes from golden yellow to greenish-brown or dark green, and the stool becomes brownish-yellow, yellowish, or beige, and later becomes a bile-free clay-like grayish-white. In the more advanced stages of the disease, a slight yellowish color may occasionally appear. The urine may become thick tea-like as the jaundice deepens, and the diaper may become yellow. The skin may be itchy and scratchy, and bleeding tendencies and impaired clotting mechanisms may occur after 2-3 months. Late stage may show severe jaundice. 2, nutritional dysplasia: In the early stage, the infant is still in good condition, but there are different degrees of malnutrition, length and weight deficiency. In the late stage of the disease, fatty malnutrition and fat-soluble vitamin deficiency symptoms may appear, and there will be malnutrition, anemia, growth retardation and slow reaction. 3, hepatosplenomegaly: early hepatosplenomegaly is normal, and rarely can be found. With the development of the disease and present progressive enlargement, about 3 months can develop into biliary cirrhosis, accompanied by ascites and portal hypertension, and the liver can be as large as below the umbilicus. If the biliary tract is not reconstructed by surgery as early as possible, the patient will eventually die about 1 year after birth due to infection, bleeding, liver failure, and liver coma. Because the disease can present normally in the early stages of life, it is extremely important to identify early obstructive bile duct disease, whether it is neonatal hepatitis syndrome or biliary atresia.